HORDB

ID: hor005949
Uniprot ID: P12961(200-212)
Protein name: C-terminal peptide
Gene name: Scg5
Organism: Mus musculus (Mouse)
Family: 7B2 family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0004857 enzyme inhibitor activity; GO:0030234 enzyme regulator activity; GO:0051082 unfolded protein binding
GO BP: GO:0006886 intracellular protein transport; GO:0007218 neuropeptide signaling pathway; GO:0016486 peptide hormone processing; GO:0046883 regulation of hormone secretion
GO CC: GO:0005576 extracellular region; GO:0005634 nucleus; GO:0030141 secretory granule

Sequence: SVPHFSEEEKEAE
Length: 13(200-212)
Propeptide: MASRLVSAMLSGLLFWLMFEWNPAFAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPLGKTADDGCLENAPDTAEFSREFQLDQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGKRLDNVVAKKSVPHFSEEEKEAE
Signal peptide: MASRLVSAMLSGLLFWLMFEWNPAFA
Modification: T6 Phosphoserine
Glycosylation: NA
Mutagenesis: NA

Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathw
Mechanism: NA
Cross BBB: NA
Target: Pcsk2
Target Unid: P21661
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005949_AF2.pdb

hor005949_ESM.pdb

Mass:	173177	Formula:	C65H96N16O26
Absent amino acids:	CDGILMNQRTWY	Common amino acids:	E
pI:	4.02	Basic residues:	2
Polar residues:	2	Hydrophobic residues:	3
Hydrophobicity:	-146.15	Boman Index:	-4223
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	30
Instability Index:	8103.85	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 2542174
Title: cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice.
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (M
PubMed ID: 9348280
Title:
PubMed ID: 10089884
Title:
PubMed ID: 8016065
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PubMed ID: 8034690
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PubMed ID: 11439082
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PubMed ID: 21183079
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